题目： Chirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots
作者：Yiye Li, Yunlong Zhou, Hai-Yan Wang, Sarah Perrett, Yuliang Zhao,* Zhiyong Tang,* and Guangjun Nie*
单位：
[*] Y. Li,[+] Prof. Y. Zhao, Prof. G. Nie
CAS Key Laboratory for Biological Effects of Nanomaterials &Nanosafety, National Center for Nanoscience and Technology
11 Beiyijie, Zhongguancun, Beijing 100190 (China)
E-mail: niegj@nanoctr.cn
H. Y. Wang, Prof. S. Perrett
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
15 Datun Road, Chaoyang District, Beijing 100101 (China)
Y. Zhou,[+] Prof. Z. Tang
Laboratory of Nanomaterials
National Center for Nanoscience and Technology, Beijing (China)
E-mail: zytang@nanoctr.cn
Prof. Y. Zhao
CAS Key Laboratory for Biological Effects of Nanomaterials &Nanosafety, Institute of High Energy Physics
Chinese Academy of Sciences (China)
E-mail: zhaoyuliang@ihep.ac.cn
[+] These authors contributed equally to this work.
[**] This work was supported by grants from MOST 973(2011CB9334001, 2010CB933600, 2009CB930401), 863 (2009AA03Z335), and the NSFC (10979011, 30900278, 20973047,21025310, 10525524, 31070656). G.N. and Z.T. gratefully acknowledge the support of the CAS Hundred Talents Program. We thank
Prof. G. Anderson for reviewing the manuscript. pEGFP-LC3 plasmid was a gift from Prof. N. Mizushima and Prof. C. Y. Jiang.
Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/anie.201008206.
Keywords:autophagy; chirality; cytotoxicity; fluorescence; quantum dots
Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).
